Ireland's Online News & Entertainment Magazine
The Minister for Public Expenditure, NDP Delivery and Reform and Digitalisation, Jack Chambers, has updated the government on the progress made on the cross-border 2021-2027 PEACEPLUS programme.
To date, PEACEPLUS has committed funding in the region of €700 million to projects supporting peace and prosperity in Northern Ireland and the border counties of Ireland. With a total value of €1.1 billion, PEACEPLUS is funded in partnership
The Minister for Rural and Community Development and the Gaeltacht, Dara Calleary, has today (24 February 2025) announced over €14 million to deliver 163 community projects across the country through the Community Recognition Fund.
The investment announced today will deliver a diverse range of projects and includes
The Minister for Finance Paschal Donohoe has signed the Commencement Order for the extension of the Alcohol Products Tax relief scheme to ‘other fermented beverages’ (OFB) other than cider and perry which was provided for in the Finance Act 2024. This new relief will operate from 1 March 2025.
The effect of this relief is to reduce the Alcohol Products Tax rate for qualifying
As Seachtain na Gaeilge approaches, the Office of Public Works (OPW) is excited to announce a series of events and tours ‘as Gaeilge’ at various locations throughout the country. This initiative aims to promote and celebrate the Irish language and culture, offering visitors a unique experience.
Visitors will have the opportunity to take tours 'in Irish' at various OPW locations
Minister for Agriculture, Food and the Marine, Martin Heydon TD, today discussed the European Commission’s ‘Vision for Agriculture and Food’ with his counterparts at the monthly meeting of the Agri-Fish Council of Ministers in Brussels.
Minister Heydon said:
“The Vision is a reassertion of the vital role of the Common Agricultural Policy
The GATA proteins with different Zinc finger domains, and the sequence comparison of GATA6 from different species.
Major signaling pathways associated with GATA6 and pancreas. Wnt antagonist dickkopf1 (DKK1) is a target gene of GATA6, and GATA6 can promote the development and carcinogenesis of the pancreas by activating the Wnt pathway via repressing of DKK1.
This new review article highlights the crucial role of GATA6, a transcription factor, in pancreatic ductal adenocarcinoma (PDA).
SHANNON, CLARE, IRELAND, February 23, 2025 /EINPresswire.com/ -- This new review article highlights the crucial role of GATA6, a transcription factor, in pancreatic ductal adenocarcinoma (PDA). The article explores GATA6’s dual role in cancer progression and its potential as a biomarker and treatment target.
Pancreatic cancer remains one of the deadliest
The UPS regulates the TME. (A) E1 ubiquitin-activating enzyme activates the carboxyl group of the C terminus of ubiquitin in an ATP-dependent manner through the formation of high-energy thioester bonds.
UPS regulates tumor cells. (A) E3 ubiquitin ligases APC/C and SCF regulate the cell cycle. MDM2, as a classical ubiquitin ligase, regulates p53 to regulate the cell cycle, while TRIM2, another E3 ligase, competes with it.
UPS regulates immune cells in the TME. DCs contact T cells via MHC to transmit antigen information.
A new review explores the pivotal role of the ubiquitin-proteasome system (UPS) in regulating the tumor microenvironment (TME) and driving cancer progression.
SHANNON, CLARE, IRELAND, February 23, 2025 /EINPresswire.com/ -- A new review published in Genes & Diseases explores the pivotal role of the ubiquitin-proteasome system (UPS) in regulating the tumor microenvironment (TME) and driving cancer progression. The study provides novel insights into how ubiquitination and deubiquitination impact tumor cells, immune responses, and potential therapeutic strategies for cancer treatment.
The tumor microenvironment is a complex
Minister for Health Jennifer Carroll MacNeill has today brought a Memo to Government regarding the situation report for urgent and emergency care in February 2025, specifically the spike in trolley numbers over the February bank holiday weekend. The Minister briefed Cabinet on recent trends over weekends, including the recent Bank Holiday weekend, the impact of those trends on patients and the next steps needed to ensure that such weekend spikes do not occur in the future.
Minister Carroll MacNeill said:
“There are two problems – the first is the underlying question of continuing to
Minister for Further and Higher Education, Research, Innovation and Science James Lawless is today making an official visit to the European Organization for Nuclear Research (CERN) with a delegation of representatives from over twenty Irish organisations.
The Minister and delegates are visiting CERN to build relationships for a fruitful
The Minister for Agriculture, Food and the Marine, Martin Heydon, has signed a new three-year Strategic Partnership Agreement with the United Nations World Food Programme (WFP).
Minister Heydon signed the agreement, co-signed by WFP Executive Director Cindy McCain, while attending WFP’s Executive Board meeting in Rome. It commits Ireland to providing €105 million in funding to the WFP, the world’s largest
